OncoReview https://www.journalsmededu.pl/index.php/OncoReview <p>The main area of <em>OncoReview’s </em>&nbsp;scientific mission is the emerging field of interdisciplinary oncology, with particular emphasis on cardio-oncology. Scientific papers published in the journal concern modern diagnostic and therapeutic methods used in this population of patients, as well as all adverse events related to anticancer treatment. Objective assessment of the benefits and risks of new oncological drugs is a unique benefit of the published works.&nbsp;<br><span lang="en-GB"><br></span><span lang="en-GB"><strong>e-ISSN: </strong>2450-6125&nbsp; <strong>&nbsp; &nbsp; &nbsp; DOI: </strong>10.24292/01.OR<br><br><strong>Indexed in:&nbsp;</strong></span><strong>SCOPUS</strong>: SJR = 0.125; SNIP = 0.099<br><span lang="en-GB">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Polish Journals Master List:&nbsp;<strong>20 points</strong>&nbsp;<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Index Copernicus: 116.25&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Google Scholar<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Polish Medical Bibliography</span></p> <p>&nbsp;</p> Medical Education sp. z o.o. en-US OncoReview 2450-6125 <p><strong>Copyright: © Medical Education sp. z o.o.</strong>&nbsp;This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (<a href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</a>), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</p> <p><em>Address reprint requests to: Medical Education, Marcin Kuźma (<a href="mailto:marcin.kuzma@mededu.pl">marcin.kuzma@mededu.pl</a>)</em></p> Prostate cancer in an elderly patient with a history of comorbidities https://www.journalsmededu.pl/index.php/OncoReview/article/view/2785 <p>Prostate cancer is the most common cancer in men in Poland. The choice of treatment method depends on many factors, including the stage of the disease, the patient's age, life expectancy, the presence of comorbidities and the general condition of the patient. Hormone therapy is one of the basic methods of prostate cancer treatment, both in adjuvant and palliative treatment. Castration-resistant prostate cancer is an incurable disease. However, the introduction of new hormonal drugs to therapy significantly extended the survival time of patients with relatively low harmfulness of therapy.</p> Adriana Stryczyńska-Mirocha Martyna Mirocha Copyright (c) 2023-03-31 2023-03-31 13 1(49) 3 5 10.24292/01.OR.131310323 Apalutamid for treatment of nonmetastatic castration-resistant prostste cancer – case study https://www.journalsmededu.pl/index.php/OncoReview/article/view/2786 <p>A special form of prostate cancer is non-metastatic castration-resistant prostate cancer. Patients with this form have rising prostate-specific antigen and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan. The phase III trials demonstrated apalutamide, darolutamide or enzalutamide to be associated with a significantly longer median metastasis-free survival. The featured description presents one case of man with non-metastatic castration- resistant prostate cancer who was treated with apalutamide.</p> Bożena Sikora-Kupis Copyright (c) 2023-03-31 2023-03-31 13 1(49) 6 8 10.24292/01.OR.131319323 Apalutamide in the treatment of non-metastatic castration-resistant prostate cancer in an elderly patient with multiple comorbidities https://www.journalsmededu.pl/index.php/OncoReview/article/view/2787 <p>Prostate cancer has been the most common malignant tumor in men in Poland since 2016 and is the second cause of death in this group of patients. The basic method of treatment in patients with advanced prostate cancer is androgen deprivation therapy, however, over time, the tumor evolves into a castration-resistant form, which poses a significant threat to the patient's life. This article presents a case of an elderly patient with internal diseases, who in the castration-resistant stage, was treated with a new generation androgen receptor blocker – apalutamide – in the first line of systemic treatment.</p> Katarzyna Liśkiewicz Copyright (c) 2023-03-30 2023-03-30 13 1(49) 9 12 10.24292/01.OR.131300323 Apalutamide as a therapeutic option in case of local failure in the nmCRPC https://www.journalsmededu.pl/index.php/OncoReview/article/view/2788 <p>Apalutamide is a non-steroidal selective androgen receptor inhibitor approved for the treatment of high-risk non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer. The paper describes a case of a patient diagnosed with prostate cancer with a long-term course of the disease. The patient was diagnosed with a non-metastatic castration-resistant stage 18 years after primary treatment. Systemic treatment with apalutamide was recommended. Initially, the treatment was carried out as part of the extended access to apalutamide program and from March 2022 as part of the B.56 drug program. The study presents the effectiveness and safety of the therapy in a 12-month follow-up period and discusses controversial aspects of the patient's previous treatments.</p> Magdalena Stankiewicz Copyright (c) 2023-04-01 2023-04-01 13 1(49) 13 19 10.24292/01.OR.131010423 Apalutamide in the treatment of a patient with non-metastatic castration-resistant prostate cancer https://www.journalsmededu.pl/index.php/OncoReview/article/view/2789 <p>The treatment of patients with prostate cancer, who do not qualify for the radical therapy is based on the use of surgical or pharmacological castration methods. The effectiveness of the so-called androgen deprivation tends to decrease over time. Even in the absence of distant metastases on imaging studies, the resistance for the hormonal castration may be developed. At this moment, the use of new generation androgen receptor inhibitors may reduce the risk of metastases or death. The paper presents a case report of a patient with prostate cancer without distant metastases who started therapy with apalutamide at the moment of developing re-sistance to the pharmacological castration.</p> Robert Dziura Copyright (c) 2023-03-31 2023-03-31 13 1(49) 20 23 10.24292/01.OR.131318323 Apalutamide as a new option for postponing metastatic disease in hormone-resistant patients with biochemical recurrence in prostate cancer https://www.journalsmededu.pl/index.php/OncoReview/article/view/2790 <p>Treatment of non-metastatic castration-resistant prostate cancer is a radically new option for cancer patients. Novel anti-hormonal therapy not only improves metastasis free survival but overall survival times and positively impacts quality of life. This case shows how apalutamide lowered tPSA level and postponed metastatic disease.</p> Bartosz Dąbek Copyright (c) 2023-04-01 2023-04-01 13 1(49) 24 26 10.24292/01.OR.131317323 Prostate cancer in clinical practice. First experiences with apalutamide within the context of therapeutic program B.56 https://www.journalsmededu.pl/index.php/OncoReview/article/view/2791 <p>The article contains a case report of patient diagnosed with castration-resistant non-metastatic prostate cancer, treated with a novel androgen receptor inhibitor – apalutamide.</p> Krzysztof Trzebiński Copyright (c) 2023-04-01 2023-04-01 13 1(49) 27 30 10.24292/01.OR.131316323 Apalutamide treatment of locally advanced prostate cancer https://www.journalsmededu.pl/index.php/OncoReview/article/view/2792 <p>Prostate cancer is most commonly diagnosed cancer in men. The choice of treatment method depends on many factors: the patient’s age, other patient’s diseases, psychophysical status and expected survival time. Hormonotherapy plays very important role in patients with no possible radical treatment. New therapies apply in patients with castration-resistant metastatic prostate cancer. First registered drug in patients with biochemical progression without metastases is apalutamide.</p> Maria Palasik Copyright (c) 2023-03-31 2023-03-31 13 1(49) 31 32 10.24292/01.OR.131315323 Plasma cell myeloma as one of the causes of bone pain in family medicine https://www.journalsmededu.pl/index.php/OncoReview/article/view/2793 <p>The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.</p> Grzegorz Kade Maciej Michalak Bartosz Kade Sebastian Spaleniak Agnieszka Podgórska Janusz Hałka Copyright (c) 2023-05-12 2023-05-12 13 1(49) 33 35 10.24292/01.OR.131120523