OphthaTherapy https://www.journalsmededu.pl/index.php/ophthatherapy <p>"OphthaTherapy. Therapies in Ophthalmology" (abbr.: OphthaTherapy) is a peer-reviewed scientific quarterly publishing papers in: ophthalmology, ophthalmic surgery (including minimally invasive surgery and laser therapy), pharmacological treatment of eye diseases, including glaucoma, as well as work in the contactology. The journal is on the list of the Polish Ministry of Science and Higher Education. For publishing the article, the author receives 20 points.<br>We encourage you to submit: original papers, review articles, case reports, rapid communication, research letters, hypotheses, meeting proceedings, letter to the editor. We guarantee fast publication. There are no submission or processing charges.</p> <p><strong>"OphthaTherapy" accepts submissions in English only. Other language versions may be published as additional ones.</strong><br><br><strong><span lang="en-GB">e-ISSN: </span></strong><span lang="en-GB">2543-9987</span><span lang="en-GB">&nbsp;</span><strong><span lang="en-GB"> &nbsp; &nbsp; &nbsp;ISSN: 2353-7175 &nbsp; &nbsp; &nbsp; DOI: </span></strong><span lang="en-GB">10.24292/01.OT<br><br></span><strong><span lang="en-GB">Indexed in:&nbsp;</span></strong><span lang="en-GB">Polish Journals Master List: <strong>20 points<br></strong>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Index Copernicus:<strong><strong class="ng-binding">72.79</strong></strong><br></span><span lang="en-GB">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Google Scholar<br></span>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Polish Scientific Journal Database<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; ARIANTA<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; WorldCat</p> Medical Education sp. z o.o. en-US OphthaTherapy 2353-7175 <p><strong>Copyright: © Medical Education sp. z o.o.</strong> License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</p> <p><em>Address reprint requests to: Medical Education, Marcin Kuźma (<a href="mailto:marcin.kuzma@mededu.pl">marcin.kuzma@mededu.pl</a>)</em></p> MicroRNA in the pathogenesis of glaucoma https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1108 <p>MicroRNAs are short ribonucleic acid molecules that regulate gene expression. The involvement of various types of microRNAs in the pathogenesis of glaucoma has been proved. Most of them affect trabecular meshwork in the anterior chamber angle, causing excessive deposition of extracellular matrix and blockage of the aqueous humor outflow. MicroRNAs affect the contractility of the trabecular meshwork cells, decreasing its permeability and increasing intraocular pressure. They participate in the regulation of apoptosis of trabecular meshwork cells and retinal ganglion cells. MicroRNAs may be potential biomarkers for glaucoma and, in the future, a target for gene therapy.</p> Karolina Gasińska Ewa Kosior-Jarecka Tomasz Żarnowski Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-09 2020-12-09 7 4 277 286 10.24292/01.OT.311220.1 Ocular myasthenia – symptoms, diagnostics, treatment https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1112 <p>Myasthenia gravis (MG) is an autoimmune disease in which antibodies are damaging receptors of the neuromuscular junction. One of its main symptoms is ptosis, term that refers to the drooping of the eyelid that may lead to a reduction of the vision field and the compensatory chin-up position. Contrary to sensile (involutional) ptosis, in which surgical treatment is a method of choice, in case of ptosis with myasthenic aetilology, pharmacotherapy is recommended and surgery is relatively contraindicated. Surgical procedures are rarely performed, only in the case of stable ptosis and ineffectiveness of pharmacotherapy. Since the majority of isolated drooping eyelids of a different aetiology can be successfully surgically corrected, ruling out the diagnosis of myasthenia gravis is essential before deciding on appropriate treatment.</p> Emilia Nowowiejska Radosław Różycki Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-15 2020-12-15 7 4 288 294 10.24292/01.OT.311220.3 The right choice of treatment regimen as the key to successful therapy of wet AMD https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1117 <p>Age-related macular degeneration remains the main cause of central vision impairment in the elderly population in developed countries. Currently, the most effective method that significantly inhibits the progression of wet AMD is intravitreal anti-VEGF injections. Not only the selection of the right active substance, but also the schedule of their administration plays an important role in proper therapy. The AMD Drug Program has significantly increased the availability of modern treatment for Polish patients. However, possible therapeutic plans still do not include the so-called treat-and-extend scheme. In our work we showed the significant advantages of the above scheme over currently available in the Polish Drug Program.</p> Agnieszka Lisiak Wojciech Suda Jarosław Kocięcki Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-17 2020-12-17 7 4 295 301 10.24292/01.OT.311220.2 An unusual presentation of corneal intraepithelial neoplasia https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1119 <p><strong>Introduction</strong>: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion.<br><strong>Clinical case</strong>: An 80-year-old woman with an elevated, avascular, well-demarcated grey corneal plaque. After epitheliectomy and alcohol, the excised lesion was identified as a high-grade epithelial neoplasia. Treatment was topical interferon α-2b for 1 month without recurrences.<br><strong>Conclusions</strong>: A well-defined greyish corneal opacity should always raise suspicion of an intraepithelial neoplasia. In the present case, epitheliectomy and topical recombinant interferon proved successful.</p> Paula Marticorena-Álvarez Guadalupe Garrido Ceca Diego Asensio Celdrán Vivancos Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 2020-12-23 2020-12-23 7 4 302 304 10.24292/01.OT.311220.4 Interaction of silicone hydrogel contact lenses with lipids – a chronological review https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1133 <p>Silicone hydrogel (SiHy) contact lenses are a common form of correction of refractive errors prescribed by eye care professionals around the world. SiHy lenses perform in a complex environment, which is the surface of the eye and the tear film. Therefore, they are exposed to various factors, such as lipid deposits. The aims of this paper are to review available scientific reports on the study of SiHy lens interactions with lipids and search for further research objectives. A total of 57 publications were identified and reviewed, from 2003 to 2020. In general, SiHy lenses are more likely to accumulate lipid deposits than traditional hydrogel lenses, although there are significant differences between SiHy lens materials that may result from different methods used in the studies. The review includes studies on various aspects of interactions between lenses and lipids, such as those concerning the effectiveness of lipids removal from lenses by care solutions. The conclusion points out future research directions, such as measurements of lipid diffusion in SiHy lens' matrices.</p> Tomasz Suliński Jacek Pniewski Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 2020-12-31 2020-12-31 7 4 306 325 10.24292/01.OT.311220.A Pediatric cataract surgery – indications for surgery, treatment techniques and postoperative procedures https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1136 <p>Currently, surgery methods of pediatric cataracts allow obtaining good visual acuity in operated children. The operation should be performed in infants over 2 months of age because of more frequent occurrence of glaucoma in earlier operated patients. In children under 10 years of age posterior capsulotomy and anterior vitrectomy are required during surgery to prevent opacification of the posterior lens capsule after surgery. Due to the frequent occurrence of opacities in the visual axis, it is recommended no to implant intraocular lenses in infants under 7<sup>th</sup> month of life (2<sup>nd</sup> year of life according to some recommendations).</p> Marek E. Prost Copyright (c) 2020 Medical Education http://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-31 2020-12-31 7 4 326 332 10.24292/01.OT.311220.9 The use of laser therapy in retinal diseases. Part III https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1121 <p>Retinal diseases account for the vast majority of ophthalmologic disorders. Over the past years, laser-based approach has been successfully used. Despite introduction of other potentially innovative, beneficial and successful therapeutic methods, lasers are still considered the gold standard. In this review, we discuss the spectrum of currently prevailing laser methods and new insights into novel perspectives and techniques regarding laser management of retinal disorders. This paper is divided into three sections. Two parts, already published in previous issues, have presented methodology with the spectrum of laser-based techniques and literature review investigating the existing knowledge in laser management of diabetic retinopathy, diabetic macular edema and vascular retinal disorders. Finally, the current one, consists of the principles guiding laser treatment of retinal tears, retinal degeneration, retinopathy of prematurity, age-related macular degeneration and other retinal diseases.</p> Katarzyna Warzecha Agnieszka Tronina Erita Filipek Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-29 2020-12-29 7 4 333 340 10.24292/10.24292/01.OT.311220.8 Laser trabeculoplasty and subthreshold transscleral cyclophotocoagulation – the new therapeutic options are modifying therapeutic algorithm in glaucoma https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1135 <p>Selective laser trabeculoplasty (SLT) and micropulse laser trabeculoplasty (MLT) are well established, non-invasive laser procedures in glaucoma, but their place in the therapeutic algorithm still evolves. Lately published multicenter randomized clinical trials indicate the need to consider laser trabeculoplasty as the first-line treatment before medications in primary open-angle glaucoma an ocular hypertension due to its favorable safety profile, efficacy and cost-effectiveness. Subthreshold transscleral cyclophotocoagulation (present on the market under different brand names: SubCyclo® TS-CPC [Quantel, France] or Cyclo G6® mTS-CPC [Iridex, USA]) is an antiglaucomatous laser procedure, recently arousing more and more interest in ophthalmologists as a new non-invasive method in our therapeutic portfolio. This new device utilizes 810 nm diode laser beam, fractionated into ultra-short pulses, resulting in low energy spots without causing ciliary body coagulation. Subthreshold (or subliminal) energy delivered during the session spares the tissue due to very limited local heat accumulation zone and therefore this procedure may be repeated. Laser energy partially disables aqueous producing ciliary epithelium and opens supraciliary space thus activating the additional outflow facility. Subthreshold TS-CPC in several clinical trials proved to be effective in lowering the intraocular pressure and devoid of significant sight threatening side effects, comparing to the classical thermal diode cyclophotocoagulation method.</p> Jaromir Wasyluk Ilona Kaczmarek Radosław Różycki Copyright (c) 2021 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 2020-12-31 2020-12-31 7 4 342 346 10.24292/01.OT.311220.11 Evaluating the availability of cataract treatment in Poland in light of institutional changes https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1120 <p>The aim of the article is to assess the access to health services in light of European Union regulatory changes, with particular emphasis on cataract procedures implemented in Poland during the years 2015–2017.</p> <p>Statistical data from the National Health Fund for the years 2015–2017 was analyzed by means of statistical description, graphical and table presentation. For parametric queues, a Student's t-test (α = 0.05) was used. For the number of submitted and paid applications under the directive, the linear trend model and the significance of the directional coefficient (α = 0.05) were used.</p> <p>The waiting queue for cataract surgery from the second quarter of 2015 to the fourth quarter of 2016 had an upward trend.</p> <p>In 2017, a drop in the number of waiting patients was observed, with a simultaneous increase in the number of applications submitted under the directive. At the same time, contract growth was observed, which translated into a decrease in the number of patients waiting for surgery in Poland. Nevertheless, no decreasing trend in the number of patients treated under the cross-border directive was observed.</p> Michał Chrobot Arnold Maciejewski Kamila Kocańda Agnieszka Strzelecka Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-23 2020-12-23 7 4 347 355 10.24292/01.OT.311220.6 Strategies to mitigate the risk from COVID-19 in ophthalmology https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1123 <p>Many countries, including Poland, are currently dealing with a second wave of COVID-19 infections. There is a pressing need to adapt to the new reality and develop new ways of working in order to deliver essential services safely. In the medical sector, there is a special need to deliver uninterrupted high quality care while minimizing the risk of disease transmission. In this article, we summarize the evidence on the transmission dynamics and ophthalmic features of COVID-19 and suggest a hierarchical approach to infection control, in order to help practitioners understand and mitigate the risks they face each day.</p> Ali Poostchi Joanna K. Dereń Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-30 2020-12-30 7 4 356 360 10.24292/01.OT.311220.10 Prof. dr hab. n. med. Ariadna Gierek-Łapińska (1938–2020) https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/1137 <p><strong>Prof. dr hab. n. med. Ariadna Gierek-Łapińska (1938–2020) </strong></p> Marek E. Prost Copyright (c) 2020 Medical Education https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-12-31 2020-12-31 7 4 361 362 10.24292/01.OT.311220.Z