OphthaTherapy. Therapies in Ophthalmology https://www.journalsmededu.pl/index.php/ophthatherapy <p>"OphthaTherapy. Therapies in Ophthalmology" (abbr.: OphthaTherapy) is a peer-reviewed scientific quarterly publishing papers in: ophthalmology, ophthalmic surgery (including minimally invasive surgery and laser therapy), pharmacological treatment of eye diseases, including glaucoma, as well as work in the contactology. The journal is on the list of the Polish Ministry of Science and Higher Education. For publishing the article, the author receives 40 points.<br>We encourage you to submit: original papers, review articles, case reports, rapid communication, research letters, hypotheses, meeting proceedings, letter to the editor. There are no submission or processing charges.</p> <p><strong>"OphthaTherapy" accepts submissions in English only. Other language versions may be published as additional ones.</strong><br><br><strong><span lang="en-GB">e-ISSN: </span></strong><span lang="en-GB">2543-9987</span><span lang="en-GB">&nbsp;</span><strong><span lang="en-GB"> &nbsp; &nbsp; &nbsp;ISSN: 2353-7175 &nbsp; &nbsp; &nbsp; DOI: </span></strong><span lang="en-GB">10.24292/01.OT<br><br></span><strong><span lang="en-GB">Indexed in: SCOPUS: CiteScore 2022 - 0.1, CiteScore Tracker 2023 - 0.2</span></strong></p> <p><span lang="en-GB">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Polish Journals Master List: <strong>20 points<br></strong>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Index Copernicus: <strong class="ng-binding">89.57</strong><br></span><span lang="en-GB">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Google Scholar<br></span>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Polish Scientific Journal Database<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; ARIANTA<br>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; WorldCat</p> en-US <p><strong>Copyright: © Medical Education sp. z o.o.</strong> License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</p> <p><em>Address reprint requests to: Medical Education, Marcin Kuźma (<a href="mailto:marcin.kuzma@mededu.pl">marcin.kuzma@mededu.pl</a>)</em></p> marcin@journalsmededu.pl (Marcin Kuźma) m.maslowski@mededu.pl (Marcin Masłowski) Sun, 31 Dec 2023 00:00:00 +0100 OJS http://blogs.law.harvard.edu/tech/rss 60 Uveal Melanoma – a review of treatment methods https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2795 <p><span data-contrast="none">Uveal melanoma is the most common primary intraocular malignancy. In Europe, the incidence of uveal melanoma is approximately 8 cases per million people per year. In about 50% of cases, uveal melanoma metastasizes. Scientific papers on uveal melanoma published between 1 January 2018 – 1 March 2023, available in the PubMed database were analysed. </span><span data-contrast="none">Currently, methods such as enucleation, transpupillary thermotherapy, photodynamic therapy, eye plaque brachytherapy, proton beam therapy and stereotactic surgery are used to treat this cancer.</span> <span data-contrast="none">In this paper we summarize the current knowledge about the classic treatment methods and the promising novel ones.</span><span data-ccp-props="{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:240}">&nbsp;</span></p> Aleksandra Domańska, Daria Piekarz, Natalia Pijas, Barbara Pieniążek, Halina Piecewicz-Szczęsna Copyright (c) 2024 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2795 Sun, 31 Dec 2023 00:00:00 +0100 Endogenous endophthalmitis with iridolenticular involvement – a case report and systematic review https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2824 <p>Endogenous endophthalmitis (EE) is a sight- and life-threatening disease. EE associated with the involvement of iris and crystalline lens is an uncommon presentation. We reported a case of EE with iridolenticular involvement in a 19-year-old woman with a history of candidemia. Therapeutic vitrectomy with lensectomy was performed, and the patient was treated with intravitreal meropenem and amphotericin B. She was discharged with 6 weeks of oral fluconazole. At follow-up, her vision was 20/60 with aphakic correction. We also conducted a systematic review of the current literature to analyse the clinical features, risk factors, and outcomes of EE with iridolenticular involvement. The systematic review included 10 cases, and found that <em>Candida albicans</em> was the main causative organism. Intravenous drug use and a history of invasive procedures were important risk factors. 70% of the cases required vitrectomy and lensectomy. Post treatment, majority of the cases (80%) had a good visual prognosis of better than 20/60. Our results suggested that in cases of EE with iridolenticular involvement, early surgical removal of the infectious nidus via vitrectomy and lensectomy is recommended for a good visual outcome. A high level of suspicion is crucial in diagnosing the disease, and early aggressive therapy is fundamental.</p> Ru Jian Jonathan Teoh, Yin Peng Lai, Rohanah Alias, Ahmad Tarmidzi Nor Azita, Swee Ying Choo Copyright (c) 2023 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2824 Fri, 22 Dec 2023 00:00:00 +0100 Peripheral hypertrophic subepithelial degeneration – case report https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2940 <p><strong>Purpose</strong>: The aim of the paper is to present the case of a 53-year-old female patient who, based on the clinical picture and optical coherent tomography of the anterior segment (AS-OCT), was diagnosed with peripheral hypertrophic subepithelial degeneration (PHSD) and underwent surgical treatment in the form of superficial keratectomy with mechanical removal of degenerative plaques.</p> <p><strong>Methods</strong>: Analysis of AS-OCT images and corneal tomography based on Scheimpflug images and surgical treatment – superficial keratectomy with mechanical removal of degenerative plaques.</p> <p><strong>Results</strong>: Before treatment, the best corrected visual acuity (BCVA) for distance, as assessed by the Snellen chart, was 3/50 c.cor +10.50/-6.50 ax 18° in the right eye (RE) and in the left eye (LE) 5/10 c.cor +10.75/-3.00 ax 48°. Preoperative keratometry performed with the Pentacam device was K1 32.7 D and K2 46.0 D in the OP and K1 42.5 D and K2 44.7 D in the LE. Postoperative BCVA in RE was 5/8 c.cor +3.50/-1.00 ax 120° at 5 months of follow-up and in LE 5/6 c.cor +4.75/-1.00 ax 64° at 3rd month of observation. Postoperative keratometry (Pentacam) in RE K1 was 44.6 D, K2 46.9 D in the 5th month of observation, and in LE K1 45.6 D, K2 46.5 D in the 3rd month of observation. As a result of the treatment, BCVA improved, astigmatism decreased and corneal translucency improved.</p> <p><strong>Conclusions</strong>: AS-OCT and Scheimpflug-based corneal tomography are helpful in the diagnosis of PHSD. Superficial keratectomy with mechanical removal of degenerative plaques seems to be an effective treatment for PHSD</p> Dorota Wyględowska-Promieńska, Łukasz Drzyzga, Dorota Śpiewak, Mariola Dorecka Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2940 Sun, 31 Dec 2023 00:00:00 +0100 Sulodexide – a new model for treating the early stages of diabetic retinopathy https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2906 <p>Glycocalyx is the surface layer of endothelial cells, it lines the blood vessels and provides a cellular barrier against damage. Sulodexide has a protective effect on the glycocalyx and allows it to be rebuilt, and has anti-inflammatory, antioxidant, anticoagulant, and lipid profile-enhancing properties. Diabetic retinopathy damages the glycocalyx and vascular endothelium in the retina. Sulodexide rebuilds the glycocalyx and increases the integrity of the blood-retinal barrier, thereby protecting the retinal vasculature retina from hyperglycemia-induced damage. Clinical studies have confirmed that in non-proliferative diabetic retinopathy, sulodexide improves visual acuity, reduces microaneurysms and hard exudates. Further in a study evaluating recurrent retinal vein thrombosis, sulodexide reduced the recurrence rate. Sulodexide is a safe and well-tolerated drug and may play an important role in the treatment of diabetic retinopathy, both in reducing symptoms and improving visual function.</p> Adam Wylęgała Copyright (c) 2020 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2906 Mon, 04 Dec 2023 00:00:00 +0100 Comparison of drugs belonging to the group of ophthalmic non-steroidal anti-inflammatory drugs https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2941 <p>Ophthalmic non-steroidal anti-inflammatory drugs are non-steroidal anti-inflammatory drugs used to treat or prevent eye inflammation. Their main action is to relieve symptoms such as pain, redness and swelling that can be caused by eye diseases, injuries or eye surgery. Non-steroidal anti-inflammatory drugs used in ophthalmology include substances such as diclofenac, ketorolac, bromfenac and nepafenac. So far, many studies have been published comparing the effectiveness of various systemic and local non-steroidal anti-inflammatory drugs. This work contains a comparative analysis of the above-mentioned substances in terms of their use and effectiveness in ophthalmology.</p> Alicja Chmura-Hołyst, Kinga Czarnacka, Bartłomiej Żaczek, Ada Pandey, Dominika Prokop, Małgorzata Gawlak, Bartosz Kuźlik, Ismael Alsoubie, Aneta Pyza, Julia Kaczmarek, Katarzyna Sajak-Hydzik, Ilona Pawlicka, Agnieszka Piskorz, Maciej Kozak, Anna Roszkowska Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2941 Sun, 31 Dec 2023 00:00:00 +0100 Resveratrol and curcumin against diabetic retinopathy. Better together than apart https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2942 <p>The health-promoting effects of curcumin and resveratrol have been known for a long time. The most important features of polyphenols include their effect on blood vessels and participation in the neutralization of free oxygen radicals. Both resveratrol and curcumin exhibit antioxidant effects, and the combined use of both substances significantly improves their effectiveness. In the fight against diabetic retinopathy, the antiangiogenic effect of polyphenols also turn out to be important. Many researchers also point to the possibility of using resveratrol and curcumin in cancer therapy.</p> Adam Kabiesz Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2942 Sun, 31 Dec 2023 00:00:00 +0100 Triple hit on ocular surface inflammation – case reports https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2944 <p>In everyday medical practice, finding the exact cause of conjunctivitis can be difficult without thorough laboratory testing. Therefore, the paper presents cases of treating ocular surface disorders of unknown etiology with the help of combination preparations in the form of a suspension, which allows a wide range of therapeutic effects including bacteria, chlamydia and allergic inflammation and provides a more stable and longer-lasting drug concentration level compared to drugs in the form of aqueous solutions.</p> Marek E. Prost Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2944 Sun, 31 Dec 2023 00:00:00 +0100 Technical aspects and intraoperative factors influencing the efficiency of non-penetrating deep sclerectomy and implantation of PreserFlo MicroShunt https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2945 <p>Glaucoma is a neurodegenerative disorder marked by the death of retinal ganglion cells which causes characteristic vision field loss. At the moment the only well-known risk factor for progression of the glaucoma is intraocular pressure. In this regard the lowering of intraocular pressure became the main focus of treatment.</p> <p>Different types of glaucoma surgeries have developed over the last decades. Most of them facilitate outflow of aqueous humor, few decrease the production. This article takes into account two of them: non-penetrating deep sclerectomy and implantation of PreserFlo MicroShunt.</p> <p>Deep sclerectomy is a well established non-penetrating type of glaucoma surgery. With use of adjuvant methods such as use of space-maintaining implants, use of viscoelastic agent and use of antimetabolites during procedure it allowed to achieve success rate of standard penetrating surgery with lower rate of complications.</p> <p>PreserFlo MicroShunt implantation is a promising new filtration procedure for glaucoma treatment. First published studies show promising efficacy and safety outcomes, although further research is needed.</p> Patrycja Soja, Piotr Jurowski Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2945 Sun, 31 Dec 2023 00:00:00 +0100 Direct brow lift – indications, diagnostics, operating techniques https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2946 <p>Eyebrow lift is one of the most effective rejuvenating procedures in facial plastic surgery. Lifting the aging soft structures around the eye socket yields both cosmetic and, in some cases, therapeutic effects. Regardless of the indications, preoperative assessment of the patient should be based on a thorough interview, establishing the patient’s expectations, determining the achievable outcome of the procedure, and anticipating potential complications. During the physical examination, it is crucial to identify relevant anatomical structures, assess facial symmetry, scope, and the technique of the procedure. Often, patients opt for combining direct eyebrow lift with eyelid surgery, significantly enhancing the overall result. The primary complication of direct eyebrow lifting is a visible scar, which may be a contraindication for individuals prone to keloid formation and those with a brow deficit. The aim of this study is to define the indications, diagnostics, and describe the surgical techniques used in eyebrow lift procedures.</p> Małgorzata Różycka, Piotr Nesterowicz, Katarzyna Różycka, Krystian Bakalarski, Katarzyna Ulaszewska, Alan Chamernik, Radosław Różycki Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0 https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2946 Sun, 31 Dec 2023 00:00:00 +0100 Ocular surface disturbances after laser refractive surgery https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2947 <p>Most patients undergoing laser refractive surgery demonstrate transient and mild symptoms of dry eye disease. The article presents the main mechanisms involved in dry eye disease after the most frequently performed laser vision correction methods. Differences in the occurrence of dry eye disease between flap, surface procedures and minimally invasive lenticule extraction were highlighted.</p> Joanna Wierzbowska Copyright (c) 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/ https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2947 Sun, 31 Dec 2023 00:00:00 +0100