Systemic contraindications for laser vision correction – an overview Review article

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Zofia Pniakowska
Piotr Jurowski
Joanna Wierzbowska


Laser vision correction (LCV) is a common corneal surgery for the treatment of refractive errors. The rapid development of LVC techniques make this procedures safe and efficient. Despite the high safety profile of corneal refractive surgery, there are however some clinical conditions that constitute absolute or relative contraindication for this procedures. The aim of the paper was to overview and summarise the currently known systemic contraindications for LVC.


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Pniakowska Z, Jurowski P, Wierzbowska J. Systemic contraindications for laser vision correction – an overview. Ophthatherapy [Internet]. 2022Dec.31 [cited 2024Jun.19];9(4):258-63. Available from:
Surgery and laser therapy


1. Ortega-Usobiaga J, Rocha-de-Lossada C, Llovet-Rausell A et al. Update on contraindications in laser corneal refractive surgery. Arch Soc Esp Oftalmol (Engl Ed). 2022; S2173-5794(22)00142-6.
2. Kraig S Bower, Woreta F. Update on contraindications for laser-assisted in situ keratomileusis and photorefractive keratectomy. Curr Opin Ophthalmol. 2014; 25(4): 251-7.
3. Kohnen T. Excimer laser refractive surgery in autoimmune diseases. J Cataract Refract Surg. 2006; 32(8): 1241.
4. Mohammadpour M. LASIK and systemic contraindications. Ophthalmology. 2007; 114(5): 1032-3.
5. Simpson RG, Moshirfar M, Edmonds JN et al. Laser in situ keratomileusis in patients with collagen vascular disease: a review of the literature. Clin Ophthalmol. 2012; 6: 1827-37.
6. Myrowitz EH. Laser-assisted intrastromal keratomileusis in a patient with systemic mastocytosis. Optometry. 2008; 79(2): 95-7.
7. Alió JL, Artola A, Belda JI et al. LASIK in patients with rheumatic diseases: a pilot study. Ophthalmology. 2005; 112(11): 1948-54.
8. Chen TY, Chu DS. Refractive surgery for the patient with autoimmune diseases. Opin Ophthalmol. 2020; 31(4): 247-52.
9. Cobo-Soriano R, Beltrán J, Baviera J. LASIK outcomes in patients with underlying systemic contraindications: a preliminary study. J Ophthalmology. 2006; 113(7): 1118.e1-8.
10. Schallhorn JM, Schallhorn SC, Hettinger KA et al. Outcomes and complications of excimer laser surgery in patients with collagen vascular and other immune-mediated inflammatory diseases. J Cataract Refract Surg. 2016; 42: 1742-52.
11. Moshirfar M, Liu HY, Rosen DB et al. Special Care in Lichen Planus Patients Undergoing LASIK: A Review Article Med Hypothesis Discov Innov Ophthalmol. 2019; 8(3): 134-8.
12. Halkiadakis I, Belfair N, Gimbel HV. Laser in situ keratomileusis in patients with diabetes. J Cataract Refract Surg. 2005; 31(10): 1895-8.
13. Fraunfelder FW, Rich LF. Laser-assisted in situ keratomileusis complications in diabetes mellitus. Cornea. 2002; 21(3): 246-8.
14. Spadea L, Paroli MP. Laser refractive surgery in diabetic patients: a review of the literature. Clin Ophthalmol. 2012;6:1775-83.
15. Simpson RG, Moshirfar M, Edmonds JN et al. Laser in-situ keratomileusis in patients with diabetes mellitus: a review of the literature. Clin Ophthalmol. 2012; 6: 1665-74.
16.Moshirfar M, Fuhriman DA, Ali A et al. Inflammatory Bowel Disease Guidelines for Corneal Refractive Surgery Evaluation. J Clin Med. 2022; 11: 4861.
17. Aman-Ullah M, Gimbel HV, Purba MK et al. Necrotizing keratitis after laser refractive surgery in patients with inactive inflammatory bowel disease. Case Rep Ophthalmol. 2012; 3(1): 54-60.
18. Moshirfar M, Barke MR, Huynh R et al. J Controversy and Consideration of Refractive Surgery in Patients with Heritable Disorders of Connective Tissue. Clin Med. 2021; 10(17): 3769.
19. Moshirfar M, Rosen DB, Heiland MB et al. Should I Get LASIK If I’m Breastfeeding? Ophthalmol Ther. 2019; 8(3): 349-52.
20. Ortega-Usobiaga J, Llovet-Osuna F, Djodeyre MR et al. Outcomes of Laser In Situ Keratomileusis and Photorefractive Keratectomy in Patients Taking Isotretinoin. Am J Ophthalmol. 2018; 192: 98-103.
21. Malik M, Simpson RC, Varma S. Isotretinoin as contraindication. BMJ. 2011; 342: d3353.
22. Ortega-Usobiaga J, Llovet-Osuna F, Reza Djodeyre M et al. LASIK and surface ablation in patients treated with amiodarone. Arch Soc Esp Oftalmol. 2016; 91(11): 520-5.
23. Hardten DR, Hira NK, Lombardo AJ. Triptans and the incidence of epithelial defects during laser in situ keratomileusis. J Refract Surg. 2005; 21: 72-6.