Sulodexide – a new model for treating the early stages of diabetic retinopathy Review article

Main Article Content

Adam Wylęgała

Abstract

Glycocalyx is the surface layer of endothelial cells, it lines the blood vessels and provides a cellular barrier against damage. Sulodexide has a protective effect on the glycocalyx and allows it to be rebuilt, and has anti-inflammatory, antioxidant, anticoagulant, and lipid profile-enhancing properties. Diabetic retinopathy damages the glycocalyx and vascular endothelium in the retina. Sulodexide rebuilds the glycocalyx and increases the integrity of the blood-retinal barrier, thereby protecting the retinal vasculature retina from hyperglycemia-induced damage. Clinical studies have confirmed that in non-proliferative diabetic retinopathy, sulodexide improves visual acuity, reduces microaneurysms and hard exudates. Further in a study evaluating recurrent retinal vein thrombosis, sulodexide reduced the recurrence rate. Sulodexide is a safe and well-tolerated drug and may play an important role in the treatment of diabetic retinopathy, both in reducing symptoms and improving visual function.

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How to Cite
1.
Wylęgała A. Sulodexide – a new model for treating the early stages of diabetic retinopathy. Ophthatherapy [Internet]. 2023Dec.4 [cited 2024May25];10(4):269-76. Available from: https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/2906
Section
Conservative treatment

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