The role of Keratosept® drops in perioperative prophylaxis in patients undergoing intravitreal injections Review article

Main Article Content

Marek Prost

Abstract

In ophthalmology intravitreal injections are one of the most commonly performed procedures. The most dangerous complication after the procedure is endophthalmitis. The most commonly used preventive measure is the application of povidone-iodine solution before and after the procedure. However, povidone has a cytotoxic effect on the epithelium of the eye surface. Therefore, it is advisable to in still Keratosept eye drops (containing 3 antiseptics, dexpanthenol, and polyvinyl alcohol) 2 days before the procedure and 3 days after to sterilize the surface of the eye before and after the injection and to facilitate the healing of changes in the conjunctival and corneal epithelium after the procedure.

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How to Cite
1.
Prost M. The role of Keratosept® drops in perioperative prophylaxis in patients undergoing intravitreal injections. Ophthatherapy [Internet]. 2025Dec.31 [cited 2026Jun.25];12(4):385-8. Available from: https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/3502
Section
Surgery and laser therapy

References

1. Singh R, Davoudi S, Ness S. Preventive factors, diagnosis, and management of injection-related endophthalmitis: a literature review. Graefes Arch Clin Exp Ophthalmol 2022; 260: 2399-416.
2. Straňák Z, Veith M, Studený P et al. The incidence of endophtalmitis after the application of intravitreal injections in FNKV with regard to various prophylactic antibiotic regimens. Cesk Slov Oftalmol. 2014; 70: 184-8.
3. Dar N, Pillar S, Friehmann A et al. Endophthalmitis after intravitreal injections versus cataract surgery: a 15-year cohort. Int Ophthalmol. 2020; 40: 73-9.
4. Prost M, Semczuk K. Antybiotykooporność szczepów bakteryjnych worka spojówkowego u dzieci. Klin Oczna. 2005; 107: 418-20.
5. Grzybowski A, Brona P, Kim SJ. Microbial flora and resistance in ophthalmology: a review. Graefes Arch Clin Exp Ophthalmol. 2017; 255: 851-62.
6. ESCRS Guidelines for Prevention and Treatment of Endophthalmitis Following Cataract Surgery: Data, Dilemmas and Conclusions. ESCRS, 2018.
7. Prost M. Profilaktyka zakażeń pooperacyjnych a problem antybiotykooporności. Okulistyka po Dyplomie. 2024; 2: 19-21.
8. Milder E, Vander J, Shah C et al. Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection. Ophthalmology. 2012; 119(7): 1420-4.
9. Grzybowski A, Brona, Kim SJ. Microbial flora and resistance in ophthalmology: a review. Graefes Arch Clin Exp Ophthalmol. 2017; 255: 851-62.
10. Kim SJ, Toma HS. Ophthalmic antibiotics and antimicrobial resistance a randomized, controlled study of patients undergoing intravitreal injections. Ophthalmology. 2011; 118: 1358-63.
11. Kanclerz P, Myers WG. Chlorhexidine and other alternatives for povidone-iodine in ophthalmic surgery: review of comparative studies. J Cataract Refract Surg. 2022; 48: 363-9.
12. Pinna A, Gavino Donadu M, Usai D et al. In vitro antimicrobial activity of a new ophthalmic solution containing povidone-iodine 0.6% (IODIM®). Acta Ophthalmol. 2020; 98: e178-80.
13. Patel SN, Gangaputra S, Sternberg P et al. Prophylaxis measures for postinjection endophthalmitis. Surv Ophthalmol. 2020; 65: 408-20.
14. Junka A. Nowoczesne antyseptyki – definicje, obszar zastosowania, mechanizmy działania i oporności. Forum Zakażeń. 2010; 1(3-4): 43-51.
15. Shibata Y, Tanaka Y, Tomita T et al. Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells. Jpn J Ophthalmol. 2014; 58: 522-7.