Molecular crosstalk between cannabinoid targets and uveitis-associated proteins: insights from network analysis Artykuł przeglądowy

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Opublikowane: paź 2, 2026
DOI: https://doi.org/10.24292/01.OT.240926
Słowa kluczowe:
idiopathic anterior uveitis, tetrahydrocannabinol, THC, protein-protein interaction, network, translational medicine

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Mehrdad Motamed Shariati
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
https://orcid.org/0000-0001-8680-5560

Abstrakt

Objectives: To map Δ9-tetrahydrocannabinol (THC) interactions within a protein– protein interaction network of idiopathic anterior uveitis.


Methods: Uveitis-related proteins were identified from the literature; THC targets (CNR1, CNR2, PPARG, TRPV1) were integrated manually. STRING database interactions (score ≥0.7) were analyzed in Python using centrality measures and Louvain clustering.


Results: The network contained 215 nodes and 10,911 edges (density 0.47). IL-6, TNF, IFN-γ, and IL-17A were hubs. PPARG bridged THC to multiple cytokines, while TRPV1 linked THC to IL-1β and IL-4. Clustering revealed cytokine and cannabinoid modules.


Conclusions: THC connects to key inflammatory mediators in idiopathic anterior uveitis via PPARG and TRPV1, suggesting translational targets for cannabinoid- based therapies.

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Motamed Shariati M. Molecular crosstalk between cannabinoid targets and uveitis-associated proteins: insights from network analysis. Ophthatherapy [Internet]. 2 październik 2026 [cytowane 3 październik 2026];00:A240926. Dostępne na: https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/3355
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Dział
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Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne – Bez utworów zależnych 4.0 Międzynarodowe.

Copyright: Medical Education sp. z o.o. License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

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