HLA-B27 acute anterior uveitis: decoding an immunological ophthalmic challenge Artykuł przeglądowy

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Opublikowane: paź 5, 2026
DOI: https://doi.org/10.24292/01.OT.251926
Słowa kluczowe:
HLA-B27, acute anterior uveitis, spondyloarthropathy, diagnosis, management

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I Gusti Made Ayu Juliari
Infection and Immunology Division, Ophthalmology Department, Prof. Ngoerah Hospital, Udayana University, Bali, Indonesia
http://orcid.org/0009-0004-1610-360X
Ida Ayu Ary Pramita Pramita
Infection and Immunology Division, Ophthalmology Department, Prof. Ngoerah Hospital, Udayana University, Bali, Indonesia
http://orcid.org/0000-0001-9579-3741
I Wayan Eka Sutyawan
Pediatric and Strabismus Division, Ophthalmology Department, Prof. Ngoerah Hospital, Udayana University, Bali, Indonesia
http://orcid.org/0000-0002-0649-3438
Michael Chandra Sarsono
Ophthalmology Resident, Prof. Ngoerah Hospital, Udayana University, Bali, Indonesia
http://orcid.org/0000-0002-8615-7388

Abstrakt

HLA-B27-associated acute anterior uveitis is a common recurrent form of non-infectious ocular inflammation. The condition is characterized by sudden- onset, unilateral anterior chamber inflammation with cells, flare, and fibrin, often accompanied by severe pain and photophobia. It is strongly linked to the HLA-B27 allele and frequently presents as an initial manifestation or comorbidity of seronegative spondyloarthropathies, including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and inflammatory bowel disease. This review outlines a distinct clinical phenotype, rationale for diagnostic testing, and a strategic management approach prioritizing acute inflammation control and long-term recurrence prevention. While timely treatment generally yields a favorable prognosis, complications like cystoid macular edema and secondary glaucoma underscore the need for multidisciplinary care and vigilant monitoring. This narrative review aims to provide a coherent clinical and pathophysiological framework to optimize patient outcomes.

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Juliari IGMA, Pramita IAAP, Sutyawan IWE, Sarsono MC. HLA-B27 acute anterior uveitis: decoding an immunological ophthalmic challenge. Ophthatherapy [Internet]. 5 październik 2026 [cytowane 23 październik 2026];00:A251926. Dostępne na: https://www.journalsmededu.pl/index.php/ophthatherapy/article/view/3436
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Copyright: Medical Education sp. z o.o. License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

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