Advances in immunotherapy for osteosarcoma: a review of emerging treatment strategies Review article

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Published: Sep 13, 2023
DOI: https://doi.org/10.24292/01.OR.132100923
Keywords:
osteosarcoma, immunotherapy, immune checkpoint inhibitors, cancer vaccines, autophagy, pyroptosis, chimeric antigen receptor T cells

Main Article Content

Kamil Poboży
Faculty of Medicine, Medical University of Warsaw, Poland
http://orcid.org/0000-0003-1260-1738
Paweł Domański
Department of Orthopedic Surgery, Ciechanów Hospital, Poland
http://orcid.org/0009-0004-2854-7128
Julia Domańska
Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw, Poland
http://orcid.org/0000-0002-4768-3561
Wojciech Konarski
Department of Orthopedic Surgery, Ciechanów Hospital, Poland
http://orcid.org/0000-0001-5542-9988
Tomasz Poboży
Department of Orthopedic Surgery, Ciechanów Hospital, Poland
http://orcid.org/0000-0002-1376-2966

Abstract

Advances in immunotherapy for osteosarcoma have shown promising results, with the use of monoclonal antibodies and immune checkpoint inhibitors. These strategies are aimed at targeting specific molecules and pathways involved in tumour immune evasion and promoting anti-tumour immune responses. Other emerging immunotherapeutic approaches include autophagy and pyroptosis induction, chimeric antigen receptor T-cell therapy, gadolinium-bisphosphonate nanoparticles and dendritic cell-based vaccines. Continued research into these emerging treatment strategies is essential for developing effective therapies for patients with high-grade osteosarcoma.

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1.
Poboży K, Domański P, Domańska J, Konarski W, Poboży T. Advances in immunotherapy for osteosarcoma: a review of emerging treatment strategies. OncoReview [Internet]. 2023Sep.13 [cited 2024May9];13(3(51):75-4. Available from: https://www.journalsmededu.pl/index.php/OncoReview/article/view/2818
Issue
Vol 13 No 3(51) (2023)
Section
PERSONALIZED ONCOLOGY
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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