Farmakoterapia nadciśnienia tętniczego w różnych populacjach. Dlaczego leki złożone, dlaczego skojarzenie telmisartanu, amlodypiny i hydrochlorotiazydu? Artykuł przeglądowy
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Abstrakt
Racjonalna farmakoterapia skojarzona nadciśnienia tętniczego opiera się na zindywidualizowanym łączeniu leków hipotensyjnych. Optymalne leczenie nadciśnienia powinno być włączane na jak najwcześniejszym etapie choroby i zapewniać pacjentowi stabilną oraz długoterminową kontrolę ciśnienia tętniczego, co przekłada się na ograniczenie ryzyka chorób układu sercowo-naczyniowego i zgonu, które są powiązane z powikłaniami nieprawidłowego leczenia nadciśnienia tętniczego. Zgodnie z aktualną wiedzą medyczną jednym z najlepszych skojarzeń leków stosowanych w terapii nadciśnienia jest skojarzenie telmisartanu, amlodypiny i hydrochlorotiazydu.
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Jak cytować
Woroń, J. (2026). Farmakoterapia nadciśnienia tętniczego w różnych populacjach. Dlaczego leki złożone, dlaczego skojarzenie telmisartanu, amlodypiny i hydrochlorotiazydu?. Medycyna Faktów , 19(2(71), 216-220. https://doi.org/10.24292/01.MF.0226.11
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Bibliografia
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3. Salam A, Atkins ER, Hsu B et al. Efficacy and safety of triple versus dual combination blood pressure-lowering drug therapy: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2019; 37: 1567-73. http://doi.org/10.1097/HJH.0000000000002089.
4. Cidda M, Mateti UV, Batchu MK et al. Study of prescribing patterns of antihypertensives in South Indian population. Int J Basic Clin Pharmacol. 2014; 3: 303-7.
5. Michel MC, Bohner H, Koster J et al. Safety of telmisartan in patients with arterial hypertension: an open-label observational study. Drug Saf. 2004; 27: 335-44.
6. Choi GJ, Kim HM, Kang H et al. Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials. Curr Med Res Opin. 2016; 32: 1303-9.
7. Wang JG, Yan P, Jeffers BW. Effects of amlodipine and other classes of antihypertensive drugs on long-term blood pressure variability: evidence from randomized controlled trials. J Am Soc Hypertens. 2014; 8(5): 340-9.
8. Messerli FH, Staessen JA. Amlodipine better than lisinopril? How one randomized clinical trial ended fallacies from observational studies. Hypertension. 2006; 48(3): 359-61.
9. Wang JG, Kario K, Lau T et al. Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: a scientific statement from the Asian Pacific Heart Association. Hypertens Res. 2011; 34(4): 423-30.
10. Ernst ME, Fravel MA. Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide. Am J Hypertens. 2022; 35(7): 573-86.
11. Whelton PK, Carey RM, Aronow WS et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018; 71(6): e13-e115.
2. Verma AA, Khuu W, Tadrous M et al. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: a population-based retrospective cohort study. PLoS Med. 2018; 15: e1002584. http://doi.org/10.1371/journal.pmed.1002584.
3. Salam A, Atkins ER, Hsu B et al. Efficacy and safety of triple versus dual combination blood pressure-lowering drug therapy: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2019; 37: 1567-73. http://doi.org/10.1097/HJH.0000000000002089.
4. Cidda M, Mateti UV, Batchu MK et al. Study of prescribing patterns of antihypertensives in South Indian population. Int J Basic Clin Pharmacol. 2014; 3: 303-7.
5. Michel MC, Bohner H, Koster J et al. Safety of telmisartan in patients with arterial hypertension: an open-label observational study. Drug Saf. 2004; 27: 335-44.
6. Choi GJ, Kim HM, Kang H et al. Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials. Curr Med Res Opin. 2016; 32: 1303-9.
7. Wang JG, Yan P, Jeffers BW. Effects of amlodipine and other classes of antihypertensive drugs on long-term blood pressure variability: evidence from randomized controlled trials. J Am Soc Hypertens. 2014; 8(5): 340-9.
8. Messerli FH, Staessen JA. Amlodipine better than lisinopril? How one randomized clinical trial ended fallacies from observational studies. Hypertension. 2006; 48(3): 359-61.
9. Wang JG, Kario K, Lau T et al. Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: a scientific statement from the Asian Pacific Heart Association. Hypertens Res. 2011; 34(4): 423-30.
10. Ernst ME, Fravel MA. Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide. Am J Hypertens. 2022; 35(7): 573-86.
11. Whelton PK, Carey RM, Aronow WS et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018; 71(6): e13-e115.