Chronic spontaneous urticaria – association with selected autoimmune diseases: a systematic review Review article
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Published:
Mar 17, 2026
Keywords:
chronic urticaria, autoimmune diseases, autoimmune thyroiditis, celiac syndrome, diabetes, systemic lupus erythematosus, rheumatoid arthritis, Sjoegren’s syndrome, myasthenia gravis
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Abstract
Urticaria is one of the most common diseases in allergological and dermatological practice. Depending on the duration of symptoms, urticaria is classified as acute or chronic. The etiology of urticaria often remains unknown, but in over 30% of cases, an association with autoimmune mechanisms is noted. This paper provides an overview of analyses examining the coexistence of chronic urticaria with selected autoimmune diseases.
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Bartosik, B., Bartosik, D., Kapeluszna, K., & Brzoza, Z. (2026). Chronic spontaneous urticaria – association with selected autoimmune diseases: a systematic review. Alergoprofil, 21(4), 9-13. https://doi.org/10.24292/01.AP.214200326
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THERAPY
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright: ? Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
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18. Kolkhir P, Borzova E, Grattan C et al. Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review. Autoimmun Rev. 2017; 16(12): 1196-1208.
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28. Lai KL, Su CC. Association of chronic urticaria with rheumatic diseases and thyroid autoimmunity. J Intern Med Taiwan. 2010; 21: 277-284.
29. Kostera-Pruszczyk A. Miastenia i zespół miasteniczny Lamberta-Eatona.
30. Rymarczyk B, Glück J, Rogala B et al. Chronic urticaria in myasthenia gravis patients – more than occasional coexistence? Allergol Immunopathol (Madr). 2014; 42(6): 626-7.
31. Darley CR, Munro DD, Borrie PF. Myasthenia gravis, systemic lupus erythematosus and urticaria. (Case 1). Myasthenia gravis and herpetiform acantholysis. (Case 2). Proc R Soc Med. 1977; 70(10): 734-7.
32. Kageyama-Yahara N, Suehiro Y, Yamamoto T et al. IgE induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2008; 377: 321-5.
33. Utsunomiya N, Yamamoto T, Kodama T et al. Pathophysiological role of the cholinergic antiinflammatory and immune pathway in a murine model of food allergy. Gastroenterology. 2006; 130: A557.
2. Leznoff A, Josse RG, Denburg J et al. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch- Dermatol. 1983; 119: 636-40.
3. Leznoff A, Sussman GL. Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients. J Allergy Clin Immunol. 1989; 84: 66-71.
4. Turktas I, Gokcora N, Demirsoy S et al. The association of chronic urticaria and angioedema with autoimmune thyroiditis. Int J Dermatol. 1997; 36: 187-90.
5. Ryhal B, DeMera RS, Shoenfeld Y et al. Are autoantibodies present in patients with subacute and chronic urticaria. J Investig Allergol Clin Immunol. 2001; 11: 16-20.
6. Verneuil L, Leconte C, Ballet JJ et al. Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients. Dermatology. 2004; 208: 98-103.
7. Palma-Carlos AG, Palma-Carlos ML. Chronic urticaria and thyroid auto-immunity. Eur Ann Allergy Clin Immunol. 2005; 37: 143-6.
8. Aamir IS, Tauheed S, Majeed F et al. Serum antithyroid antibodies in female patients with chronic urticaria; J Coll Physicians Surg Pak. 2008; 18(8): 498-501.
9. Czarnecka-Operacz M, Sadowska-Przytocka A, Jenerowicz D et al. Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria. Adv Dermatol Allergol. 2017; XXXIV(6): 566-72.
10. Delèvaux I, André M, Tridon A et al. Chronic urticaria and Hashimoto-Hashimoto’s thyroiditis: report of 6 cases. Rev- Med Intern. 2001; 22: 232-7.
11. Kandeel AA, Zeid M, Helm T et al. Evaluation of chronic urticaria in patients with Hashimoto thyroiditis. J Clin Immunol. 2001; 21: 335-47.
12. Concha LB, Chang CC, Szema AM et al. IgE antithyroid antibodies in patients with Hashimoto’s disease and chronic urticaria. Allergy Asthma Proc. 2004; 25: 293-6.
13. Hautekeete ML, DeClerck LS, Stevens WJ. Chronic urticaria associated with coeliac disease. Lancet. 1987; 1(8525): 157.
14. Haussmann J, Sekar A. Chronic urticaria: A cutaneous manifestation of celiac disease. Can J Gastroenterol. 2006; 20(4): 291-3.
15. Scala E, Giani M, Pirrotta L et al. Urticaria and adult celiac disease. Allergy. 1999; 54: 1008-9.
16. Confino-Cohen R, Chodick G, Shalev V et al. Chronic urticaria and autoimmunity: associations found in a large population study. J. Allergy Clin. Immunol. 2012; 129(5): 1307-13.
17. Ludvigsson JF, Lindelöf B, Rashtak S et al. Does urticaria risk increase in patients with celiac disease. A large population- based cohort study. Eur J Dermatol. 2013; 23(5): 681-7.
18. Kolkhir P, Borzova E, Grattan C et al. Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review. Autoimmun Rev. 2017; 16(12): 1196-1208.
19. Fraser K, Robertson L. Chronic urticaria and autoimmunity. Skin Therapy Lett. 2013; 18(7): 5-9.
20. Hyman SJ, Shreffler WG, Rapaport R. Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria. Pediatr Diabetes. 2008; 9(5): 508-11.
21. Mazzetti A, Borici-Mazi R. Childhood chronic urticaria and type 1 diabetes. Allergy Asthma Clin Immunol. 2011; 7(Suppl 2): A18.
22. Kolkhir P, Pogorelov D, Olisova O et al. Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus – a systematic review. Clin Exp Allergy. 2016; 46(2): 275-87.
23. Kolkhir P, Borzova E, Grattan C et al. Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review. Clin Exp Allergy. 2016; 46(2): 275-87.
24. Sánchez J, Sánchez A, Cardona R. Prevalence of Drugs as Triggers of Exacerbations in Chronic Urticaria. J Investig Allergol Clin Immunol. 2019; 29(2): 112-7.
25. Balamurugesan K, Davis P, Ponprabha R et al. Chloroquine induced urticaria: A newer adverse effect. J Family Med Prim Care. 2019; 8(7): 2545-7.
26. Spadoni M, Jacob C, Aikawa N et al. Chronic autoimmune urticaria as the first manifestation of juvenile systemic lupus erythematosus. Lupus. 2011; 20(7): 763-6.
27. Kavanaugh A, Tomar R, Reveille J et al. Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med. 2000; 124: 71-81.
28. Lai KL, Su CC. Association of chronic urticaria with rheumatic diseases and thyroid autoimmunity. J Intern Med Taiwan. 2010; 21: 277-284.
29. Kostera-Pruszczyk A. Miastenia i zespół miasteniczny Lamberta-Eatona.
30. Rymarczyk B, Glück J, Rogala B et al. Chronic urticaria in myasthenia gravis patients – more than occasional coexistence? Allergol Immunopathol (Madr). 2014; 42(6): 626-7.
31. Darley CR, Munro DD, Borrie PF. Myasthenia gravis, systemic lupus erythematosus and urticaria. (Case 1). Myasthenia gravis and herpetiform acantholysis. (Case 2). Proc R Soc Med. 1977; 70(10): 734-7.
32. Kageyama-Yahara N, Suehiro Y, Yamamoto T et al. IgE induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2008; 377: 321-5.
33. Utsunomiya N, Yamamoto T, Kodama T et al. Pathophysiological role of the cholinergic antiinflammatory and immune pathway in a murine model of food allergy. Gastroenterology. 2006; 130: A557.