Why is it worth considering intramuscular injections in the first stages of therapy? Review article
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Published:
Nov 30, 2023
Keywords:
acute pain, analgesic treatment, meloxicam, non-steroidal anti-inflammatory drugs, vitamin B12
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Abstract
The paper describes methods to improve the effectiveness and safety of analgesic treatment using meloxicam. The main emphasis was placed on obtaining a quick therapeutic effect by the using of intramuscular administration and strengthening the analgesic effect by adding vitamin B12.
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How to Cite
Walewska, E. (2023). Why is it worth considering intramuscular injections in the first stages of therapy?. Medycyna Faktow (J EBM), 16(3(60), 348-350. https://doi.org/10.24292/01.MF.0323.12
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References
1. Euller-Ziegler L, Vélicitat P, Bluhmki E et al. Meloxicam: a review of its pharmacokinetics, efficacy and tolerability following intramuscular administration. Inflamm Res. 2001; 50: 5-9.
2. Hawkey C, Kahan A, Steinbrück K et al. Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. Br J Rheumatol. 1998; 37(9): 937-45.
3. Vaccarino V, Sirtori C, Bufalino L. Local and systemic tolerability of piroxicam after intramuscular administration in healthy volunteers. Curr Ther Res. 1989. 45(1): 1-13.
4. Ghozlan P, Bernhardt M, Vélicitat P, Bluhmki E. Tolerability of multiple administration of intramuscular meloxicam: a comparison with intramuscular piroxicam in patients with rheumatoid arthritis or osteoarthritis. Br J Rheumatol. 1996; 35(suppl 1): 51-5.
5. Auvinet B, Ziller R, Appelboom T, Velicitat P. Comparison of the onset and intensity of action of intramuscular meloxicam and oral meloxicam in patients in acute sciatica. Clin Ther. 1995; 17(6): 1078-90.
6. Combe B, Vélicitat P, Garzón N, Bluhmki E. Comparison of intramuscular and oral meloxicam in rheumatoid arthritis patients. Inflamm Res. 2001; 50: 10-6.
7. Redmond A. Efficacy of vitamin B12 in the alleviation of the lightning pains of tabes dorsalis. Br J Ven Dis. 1957; 33(2): 118.
8. Calderon-Ospina C-A, Nava-Mesa MO, Arbeláez Ariza CE. Effect of combined diclofenac and B vitamins (thiamine, pyridoxine, and cyanocobalamin) for low back pain management: systematic review and meta-analysis. Pain Med. 2020; 21(4): 766-81.
9. Suzuki K, Tanaka H, Ebara M, et al. Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional recovery in a rat sciatic nerve crush injury model. Acta Biomater. 2017; 53: 250-9.
10. Hosseinzadeh H, Moallem SA, Moshiri M et al. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice. Arzneimittelforschung. 2012; 62(07): 324-9.
11. Bhatia P, Singh N. Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol. 2015; 29(6): 522-8.
12. Jurna I. Analgesic and analgesia-potentiating action of B vitamins. Der Schmerz. 1998; 12: 136-41.
13. Paez-Hurtado A, Calderon-Ospina C, Nava-Mesa M. Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review. Nutr Neurosci. 2022: 1-19.
14. Mauro GL, Martorana U, Cataldo P et al. Vitamin B~ 1~ 2 in low back pain: A randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000; 4: 53-8.
15. Wang J, Wu YH, Liu SJ et al. Vitamin B12 for herpetic neuralgia: a meta-analysis of randomised controlled trials. Complement Ther Med. 2018; 41: 277-82.
16. Karaganis S, Song XJ. B vitamins as a treatment for diabetic pain and neuropathy. J Clin Pharm Ther. 2021; 46(5): 1199-212.
2. Hawkey C, Kahan A, Steinbrück K et al. Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment. Br J Rheumatol. 1998; 37(9): 937-45.
3. Vaccarino V, Sirtori C, Bufalino L. Local and systemic tolerability of piroxicam after intramuscular administration in healthy volunteers. Curr Ther Res. 1989. 45(1): 1-13.
4. Ghozlan P, Bernhardt M, Vélicitat P, Bluhmki E. Tolerability of multiple administration of intramuscular meloxicam: a comparison with intramuscular piroxicam in patients with rheumatoid arthritis or osteoarthritis. Br J Rheumatol. 1996; 35(suppl 1): 51-5.
5. Auvinet B, Ziller R, Appelboom T, Velicitat P. Comparison of the onset and intensity of action of intramuscular meloxicam and oral meloxicam in patients in acute sciatica. Clin Ther. 1995; 17(6): 1078-90.
6. Combe B, Vélicitat P, Garzón N, Bluhmki E. Comparison of intramuscular and oral meloxicam in rheumatoid arthritis patients. Inflamm Res. 2001; 50: 10-6.
7. Redmond A. Efficacy of vitamin B12 in the alleviation of the lightning pains of tabes dorsalis. Br J Ven Dis. 1957; 33(2): 118.
8. Calderon-Ospina C-A, Nava-Mesa MO, Arbeláez Ariza CE. Effect of combined diclofenac and B vitamins (thiamine, pyridoxine, and cyanocobalamin) for low back pain management: systematic review and meta-analysis. Pain Med. 2020; 21(4): 766-81.
9. Suzuki K, Tanaka H, Ebara M, et al. Electrospun nanofiber sheets incorporating methylcobalamin promote nerve regeneration and functional recovery in a rat sciatic nerve crush injury model. Acta Biomater. 2017; 53: 250-9.
10. Hosseinzadeh H, Moallem SA, Moshiri M et al. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice. Arzneimittelforschung. 2012; 62(07): 324-9.
11. Bhatia P, Singh N. Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol. 2015; 29(6): 522-8.
12. Jurna I. Analgesic and analgesia-potentiating action of B vitamins. Der Schmerz. 1998; 12: 136-41.
13. Paez-Hurtado A, Calderon-Ospina C, Nava-Mesa M. Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review. Nutr Neurosci. 2022: 1-19.
14. Mauro GL, Martorana U, Cataldo P et al. Vitamin B~ 1~ 2 in low back pain: A randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000; 4: 53-8.
15. Wang J, Wu YH, Liu SJ et al. Vitamin B12 for herpetic neuralgia: a meta-analysis of randomised controlled trials. Complement Ther Med. 2018; 41: 277-82.
16. Karaganis S, Song XJ. B vitamins as a treatment for diabetic pain and neuropathy. J Clin Pharm Ther. 2021; 46(5): 1199-212.