The use of tapentadol in the practice of a neurologist Review article
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Published:
May 31, 2026
Keywords:
tapentadol, opioids, pain
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Abstract
Tapentadol is a strong opioid with a unique mechanism of action. It is an agonist at μ-opioid receptors and inhibits norepinephrine reuptake. The first mechanism of action makes tapentadol useful in the treatment of acute pain of moderate to severe intensity, while the second justifies its use in chronic pain. The drug can be used for nociceptive, neuropathic, and mixed pain. Compared to other opioids, it has a better efficacy and safety profile. It has a low risk of adverse drug interactions. It is a good therapeutic option for both elderly patients with multiple morbidities and young, professionally active individuals.
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How to Cite
Bielewicz, J. (2026). The use of tapentadol in the practice of a neurologist. Medycyna Faktow (J EBM), 19(1(70), 88-93. https://doi.org/10.24292/01.MF.0126.12
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References
1. Vargas-Schaffer G. Is the WHO analgesic ladder still valid? Twenty-four years of experience. Can Fam Physician. 2010; 56(6): 514-7.
2. Woroń J. Opioidowe leki przeciwbólowe. Chirurgia po Dyplomie. 2017; 06: 12-26.
3. Krajnik M, Żylicz Z. Mechanizmy działania przeciwbólowego opioidów. Polska Medycyna Paliatywna. 2003; 2(2): 111-8.
4. Zaporowska-Stachowiak I, Oduah MT, Celichowska M et al. Opioidy w Praktyce Klinicznej. Varia Medica. 2020; 4(1): 43-51.
5. Attal N, Cruccu G, Baron R et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010; 17(9): 1113-e88.
6. Malec-Milewska M, Woroń J (eds.). Kompendium leczenia bólu. Medical Education, Warszawa 2017.
7. Pergolizzi J, Böger RH, Budd K et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008; 8(4): 287-313.
8. Ahlbeck K. Opioids: a two-faced Janus. Curr Med Res Opin. 2011; 27(2): 439-48.
9. Jang HN, Oh TJ. Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy. Diabetes Metab J. 2023; 47(6): 743-56.
10. Zavaleta-Monestel E, Anchía-Alfaro A, Villalobos-Madriz J et al. Tapentadol: A Comprehensive Review of Its Role in Pain Management. Cureus. 2024; 16(11): e74307.
11. Deeks ED. Tapentadol Prolonged Release: A Review in Pain Management. Drugs. 2018; 78(17): 1805-16.
12. Caputi FF, Nicora M, Simeone R et al. Tapentadol: an analgesic that differs from classic opioids due to its noradrenergic mechanism of action. Minerva Med. 2019; 110(1): 62-78.
2. Woroń J. Opioidowe leki przeciwbólowe. Chirurgia po Dyplomie. 2017; 06: 12-26.
3. Krajnik M, Żylicz Z. Mechanizmy działania przeciwbólowego opioidów. Polska Medycyna Paliatywna. 2003; 2(2): 111-8.
4. Zaporowska-Stachowiak I, Oduah MT, Celichowska M et al. Opioidy w Praktyce Klinicznej. Varia Medica. 2020; 4(1): 43-51.
5. Attal N, Cruccu G, Baron R et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010; 17(9): 1113-e88.
6. Malec-Milewska M, Woroń J (eds.). Kompendium leczenia bólu. Medical Education, Warszawa 2017.
7. Pergolizzi J, Böger RH, Budd K et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008; 8(4): 287-313.
8. Ahlbeck K. Opioids: a two-faced Janus. Curr Med Res Opin. 2011; 27(2): 439-48.
9. Jang HN, Oh TJ. Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy. Diabetes Metab J. 2023; 47(6): 743-56.
10. Zavaleta-Monestel E, Anchía-Alfaro A, Villalobos-Madriz J et al. Tapentadol: A Comprehensive Review of Its Role in Pain Management. Cureus. 2024; 16(11): e74307.
11. Deeks ED. Tapentadol Prolonged Release: A Review in Pain Management. Drugs. 2018; 78(17): 1805-16.
12. Caputi FF, Nicora M, Simeone R et al. Tapentadol: an analgesic that differs from classic opioids due to its noradrenergic mechanism of action. Minerva Med. 2019; 110(1): 62-78.