Fosfomycin as a first-line drug? A two-case study from an internist’s perspective Case report
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Published:
May 31, 2026
Keywords:
infection, urinary tract, fosfomycin
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Abstract
The paper presents the basic principles of treatment of simple, uncomplicated urinary tract infections. The important role and therapeutic efficacy of fosfomycin is showed. Two clinical cases indicating its correct use are discussed and various situations allowing for therapy with this antibiotic are revealed.
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How to Cite
Sapilak, B. J. (2026). Fosfomycin as a first-line drug? A two-case study from an internist’s perspective. Medycyna Faktow (J EBM), 19(1(70), 117-121. https://doi.org/10.24292/01.MF.0126.16
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References
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5. EAU guidelines on urological infections.
6. Hryniewicz W, Holecki M, Duława J et al. Rekomendacje diagnostyki, terapii i profilaktyki zakażeń układu moczowego u dorosłych.
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8. Polat M, Ozkaya-Parlakay A, Tapısız A et al. Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant Escherichia coli in female adolescents. J Chemother. 2022; 34(2): 97-102.
9. Barr WH, Lin CC, Radwanski E et al. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991; 14: 93-100.
10. Naber KG, Schitob G, Bottoc H et al. Surveillance Study in Europe and Brazil on Clinical Aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): Implications for Empiric Therapy. Eur Urol. 2008; 54 (5): 1164-78.
11. EAU Guidelines Office, Arnhem, the Netherlands.
12. Możdżan M, Loba J, Ruxer J et al. The Efficacy of Chronic Therapy of Recurrent Lower Urinary Tract Infections with Fosfomycin and Nitrofurantoin in Type 2 Diabetic Patients. Adv Clin Exp Med. 2007; 16(6): 777-84.
2. Babska K. Prewencja zakażeń układu moczowego u pacjentów z cewnikiem moczowym. Forum Nefrologiczne. 2020; 13 (2): 98-102.
3. Bent S, Nallamothu BK, Simel DL et al. Does this woman have an acute uncomplicated urinary tract infection? JAMA. 2002; 287: 2701-10.
4. Hooton T. Urinary tract infection in adults. In: Comprehensive Clinical Nephrology (5th ed.). Floege J, Johnson R, Feehally J (eds.). Elsevier/ Saunders, Philadelphia, PA 2015.
5. EAU guidelines on urological infections.
6. Hryniewicz W, Holecki M, Duława J et al. Rekomendacje diagnostyki, terapii i profilaktyki zakażeń układu moczowego u dorosłych.
7. Qiao LD, Chen S, Yang Y et al. Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study. BMJ Open. 2013; 3: e004152.
8. Polat M, Ozkaya-Parlakay A, Tapısız A et al. Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant Escherichia coli in female adolescents. J Chemother. 2022; 34(2): 97-102.
9. Barr WH, Lin CC, Radwanski E et al. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991; 14: 93-100.
10. Naber KG, Schitob G, Bottoc H et al. Surveillance Study in Europe and Brazil on Clinical Aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): Implications for Empiric Therapy. Eur Urol. 2008; 54 (5): 1164-78.
11. EAU Guidelines Office, Arnhem, the Netherlands.
12. Możdżan M, Loba J, Ruxer J et al. The Efficacy of Chronic Therapy of Recurrent Lower Urinary Tract Infections with Fosfomycin and Nitrofurantoin in Type 2 Diabetic Patients. Adv Clin Exp Med. 2007; 16(6): 777-84.